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KMID : 0861020110260010029
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Korea Journal of Herbology
2011 Volume.26 No. 1 p.29 ~ p.33
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Effects of Angelica Gigantis Radix Extracts on the Collagenase Activity and Procollagen Synthesis in HS68 Human Fibroblasts and Tyrosinase Activity
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Lee Jung-Hun
Lee Se-Na
Kim Myung-Gyou
Kim Myoung-Hee
Kim Hyung-Jun
Jo Hak-Jun
Leem Kang-Hyun
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Abstract
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Objectives:This study was designed to investigate the collagen metabolism and tyrosinase activity of Angelicae Gigantis Radix extracts (AGR).
Methods:The effect of AGR on type I procollagen production and collagenase activity in human normal fibroblasts HS68 after UVB (312 nm) irradiation was measured by ELISA method. The tyrosinase activity after treatment of AGR was measured.
Results: Type I procollagen production was recovered by AGR in UVB damaged HS68 cells. The increased collagenase activity after UVB damage was significantly recovered by AGR and the tyrosinase activity was significantly reduced. However, the L-DOPA oxidation was not changed.
Conclusion:AGR showed the anti-wrinkle effects and whitening effects in vitro. These results suggest that AGR may have potential as an anti-aging ingredient in cosmetic herbs.
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KEYWORD
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Angelicae Gigantis Radix, type I procollagen, collagenase, tyrosinase
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